Symbol
Name
ID

Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

decreased T cell apoptosis

decreased NK cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased Ly6C high monocyte number

increased leukocyte cell number

abnormal mononuclear phagocyte morphology

abnormal osteoclast morphology

abnormal immunoglobulin level

decreased IgG1 level

decreased IgG2a level

decreased IgG3 level

decreased IgM level

abnormal NK cell physiology

impaired natural killer cell mediated cytotoxicity

abnormal CD8-positive, alpha-beta T cell physiology

abnormal macrophage physiology

increased circulating interleukin-12 level

abnormal cytokine level

abnormal dendritic cell physiology

abnormal cytokine secretion

decreased interferon-alpha secretion

decreased interferon-beta secretion

abnormal interferon-gamma secretion

decreased interleukin-6 secretion

decreased tumor necrosis factor secretion

abnormal inflammatory response

abnormal response to infection

abnormal susceptibility to infection

increased susceptibility to bacterial infection induced morbidity/mortality

increased susceptibility to Herpesvirales infection induced morbidity/mortality

increased susceptibility to Coronaviridae infection induced morbidity/mortality

increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality

increased susceptibility to Paramyxoviridae infection induced morbidity/mortality

increased susceptibility to Picornaviridae infection induced morbidity/mortality

increased susceptibility to Togaviridae infection induced morbidity/mortality

increased susceptibility to Adenoviridae infection

increased susceptibility to Herpesvirales infection

increased susceptibility to Poxviridae infection

decreased susceptibility to Coronaviridae infection

increased susceptibility to Coronaviridae infection

increased susceptibility to Orthomyxoviridae infection

increased susceptibility to Paramyxoviridae infection

increased susceptibility to Picornaviridae infection

increased susceptibility to Togaviridae infection

increased susceptibility to Riboviria infection

Availability

Mouse Genotype

Ifnar1^m1Btlr/Ifnar1^m1Btlr

Ifnar1^m2Btlr/Ifnar1^m2Btlr

Ifnar1^tm1Agt/Ifnar1^tm1Agt

Ifnar1^tm1Pjh/Ifnar1^tm1Pjh

Cd19^tm1(cre)Cgn/Cd19⁺
Ifnar1^tm1Uka/Ifnar1^tm1Uka (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23